Commey ready to “give everything” in Lopez bout

first_imgIBF Lightweight world champion, Richard Commey, says he is willing to put in all effort to defeat challenger, Teofimo Lopez, on December 14 in their bout in New York’s Madison Square Garden.Commey has been getting ready for the bout which was put together in September this year after Lopez defeated Japan’s Masayoshi Nakatani to become the number one contender in the division.The December 14 bout is very important for the two boxers since it holds the key to  a potential unification bout with Vasyl Lomachenko who holds all the other belts in the division.For Commey, he believes he is ready to face Lopez and he is promising to give his very best.“I am going to do what I do best and joy myself. This is a major bout for me and it holds the future. I am working hard in the gym and I am not taking anything for granted.God knows why I got this opportunity and I believe He has something good for me and definitely, I will defend my title.”Commey added that even though he had been training and getting ready for the bout, he would have a better idea of Lopez’s quality and abilities on the night of the bout.“I cannot really say much in terms of what Lopez can do. I have seen bits of him but in the ring, he will be totally different. That is where I will see what he really has.”Commey’s bout with Lopez represents his second defence of the IBF Lightweight title. After winning it against Isa Chaniev in February this year, he defeated Ray Beltran in June for his first defence.last_img read more

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Researchers develop biofilm formulations that protect from necrotizing enterocolitis

first_imgJul 11 2018Most of the time, we think biofilms are bad news. And when pathogenic microbes form biofilms, they are. The biofilms created by pathogenic microbes create fortresses that make them resistant to attack by the immune system and to current antimicrobial treatments. These fortresses make eradicating infections difficult.But what if you could use biofilms for good? That’s just what Gail Besner, MD, Steve Goodman, PhD, Michael Bailey, PhD, Lauren Bakaletz, PhD, and their teams at Nationwide Children’s Hospital are investigating.They have developed Lactobacillus reuteri biofilm formulations that protect against experimental necrotizing enterocolitis (NEC), first described in Journal of Pediatric Surgery in 2016. A new iteration of the technology may help further reduce the incidence of NEC.”NEC is a devastating problem for premature infants. Despite decades of research, 10 percent of infants born under 1500 g will develop NEC, and we haven’t made significant progress in the prevention or treatment over the years – mortality remains as high as 30 percent for these babies,” says Dr. Besner, chief of Pediatric Surgery at Nationwide Children’s.Bacterial colonization of the infant’s gut is critical to healthy development. Although variability exists among individuals, premature infants tend to have reduced microbiome diversity and stability, and increased numbers of pathogenic Gammaproteobacteria, according to the publication.”Using probiotics to treat NEC is not a new idea, but administering free-living probiotics has had variable results in clinical trials,” explains Dr. Besner, also a professor of Surgery and Pediatrics at The Ohio State University. “Our idea was to develop a safe, effective delivery mechanism to support a one-dose treatment to prevent NEC. In our animal models of the disease, this is what we appear to have accomplished.”To create the biofilm, cultures of L. reuteri are introduced to porous, biocompatible, biodegradable 50 μm diameter dextranomer microspheres. During a brief incubation, the bacteria adhere to the microspheres and form a biofilm. In the biofilm state, the probiotics have increased resistance to gastric acidity and increased adherence to the gastrointestinal mucosa compared to free-floating bacteria.Now, the team has published the results of their latest iteration of the technology – testing the effects of enhancing the microspheres with sucrose or maltose as diffusible cargo. The study, published in American Journal of Physiology, reports enhanced performance of the single dose L. reuteri biofilm in experimental NEC.Related StoriesBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryNew research could help design algae that produces fuels and cleanup chemicalsNew network for children and youth with special health care needs seeks to improve systems of careAccording to the authors, in addition to reducing the incidence of NEC in animals, the enhanced formulation improved animal survival, reduced intestinal mucosal barrier breakdown and limited intestinal inflammation. The L. reuteri microspheres loaded with maltose also augmented the persistence of numerous Lactobacillus species in the intestinal tract and shifted the gut microbiome to be more similar to that of breast-fed babies.”Given the microbiome disruption observed in preterm infants who go on to develop NEC, a treatment that preserves the microbiome holds great promise as an intervention to prevent NEC,” says Dr. Besner, who is senior author of the recent publication. “Furthermore, our novel probiotic delivery system limits the expansion of pathogenic bacteria such as Enterobacter species, providing further evidence that it attenuates detrimental NEC-induced dysbiosis.”All of the components – the probiotic, the microsphere, the sucrose/maltose – used in the proposed intervention are “Generally Recognized as Safe” (GRAS) by the U.S. Food and Drug Administration (FDA). The scientists hope that this will be an advantage as they begin to work to develop clinical trials using the L. reuteri biofilm preparation.”The use of these microspheres represents an exciting development in improved probiotic administration. As we continue to learn more about the human microbiome and its relationship to health and disease, probiotic administration may play an increasingly important role in disease prevention and management – not just for the application to NEC,” says Dr. Besner.Previous clinical trials of probiotics to prevent NEC have had variable results. Dr. Besner and her colleagues believe that the novel delivery system that they have developed will offer significant advantages over L. reuteri delivered in its free-living form. To that end, they are in talks with the FDA to design a clinical trial to test the delivery system in humans. Source:https://www.nationwidechildrens.org/last_img read more

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